Day

June 4, 2014

Scientists Uncover Features of Antibody-Producing Cells in People Infected with HIV

Using advanced tools to probe B-cell responses to HIV and other pathogens in the laboratory, the researchers found that the B cells that make antibodies to HIV in infected, untreated people are abnormal in that they are more activated, unstable and unresponsive to further stimulation than normal B cells, and also are infrequently observed in healthy people. This finding may help explain why HIV-specific antibodies naturally produced by HIV-infected people do not clear the infection, according to the scientists.